Which of the following is associated with Y chromosome ?
Hypertrichosis of the ear is the abnormal growth of hair on the external ear. It is a Y-linked trait. The hairy-eared males carried Y chromosomes from many haplogroups of the Y-phylogeny. According to a hypothesis of Y-linkage, it would require multiple independent mutations within a single population.
The Y chromosome is one of the two sex chromosomes in humans (X and Y). It is male-determining, meaning individuals with one X and one Y chromosome (XY) develop as males. The Y chromosome carries genes that are crucial for male sexual development, such as the SRY gene (Sex-determining Region Y), which triggers testis formation.
Key points about Y-linked inheritance:
Step 1: Evaluate "Hypertrichosis of ears" – This is a rare condition characterized by excessive hair growth on the outer ear. It is Y-linked, meaning it is passed from father to son and is associated with the Y chromosome.
Step 2: Evaluate "Night blindness" – Night blindness can be caused by vitamin A deficiency or genetic factors. Genetic forms are often autosomal recessive (e.g., retinitis pigmentosa) or X-linked recessive, not Y-linked.
Step 3: Evaluate "Haemophilia" – Haemophilia is a bleeding disorder caused by mutations in genes on the X chromosome (e.g., Factor VIII or IX). It is X-linked recessive and affects males more frequently, but it is not Y-linked.
Step 4: Evaluate "Colour blindness" – Colour blindness is most commonly due to mutations in genes on the X chromosome (e.g., red-green colour blindness). It is X-linked recessive and not associated with the Y chromosome.
Final Answer: Hypertrichosis of ears is associated with the Y chromosome.
Inheritance Patterns:
Probability in Genetics (for X-linked recessive):
For a carrier female (XcX) and normal male (XY), the probability of an affected son is:
Key Formulae:
Hardy-Weinberg Principle for allele frequencies:
where is frequency of dominant allele, is frequency of recessive allele.